A recent study from the Max Planck Institute of Biochemistry introduces spatial medicine, merging spatial biology with therapeutic applications, particularly in addressing toxic epidermal necrolysis (TEN). Utilizing spatial transcriptomics and deep visual proteomics, researchers mapped cellular interactions in TEN patients, uncovering key protein signaling pathways related to the disease's inflammatory responses. This innovative approach not only clarified the mechanisms behind TEN but also led to the application of Janus kinase (JAK) inhibitors in preclinical models, which proved effective in reducing inflammation and severity, ultimately resulting in successful treatments for seven patients.
